Stefano Raffaele was born in Milan and made his professional comics debut as an artist with the series Lazarus Ledd, written by Ade Capone, for Star Comics. With Capone, he also created the mini-series The Power and the Glory, the first Italian superhero comic. In 1995, Raffaele began working for the American market, with stints on Hawkeye and X-Factor. He set up his Quantumdream studios in 2001 and created his first solo project, Loving Dead (also known as Fragile), in 2003. In the mid-2000s, Stefano migrated to the European market where he teamed up with scribe Christophe Bec to create the horror series Pandemonium, based on the Waverly Hills Sanatorium legend. The project served as a launching pad for an on-going collaboration with the prolific Bec, including another horror outing, The Shadows of Salamanca, also published by Humanoids.