Mechanism of Autoregulation in the Intact Kidney

Lerner B. Hinshaw · Thomas E. Emerson · Charles M. Brake

1963年1月 · U.S. Government Printing Office

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The subject of the investigation is the mechanism of autoregulation of blood flow in the intact kidney. The left kidney of the anesthetized dog was exposed via a flank approach. Renal venous outflow was measured during control periods and following separate elevations of renal artery pressure, renal vein pressure, and ureteral pressure. Extravascular pressure (tissue pressure) was estimated by obtaining values of (a) deep vein pressure; (b) needle pressure; (c) and (d) large vein pressure and ureteral pressure elevations resulting in significant decreases in renal blood flow. Results are in agreement with previously reported studies regarding the important role of extravascular pressure in autoregulation. Increases in renal artery pressure result in elevations of extravascular pressure which compress the renal vasculature. Increases in renal vein and ureteral pressures did not decrease renal blood flow until approximating or exceeding resting tissue pressure. Results from carotid artery occlusion experiments indicate that extrarenal humoral influences may be superimposed on the autoregulatory phenomenon. (Author).