Molecular Theory of the Living Cell: Concepts, Molecular Mechanisms, and Biomedical Applications

· Springer Science & Business Media
3,0
1 avis
E-book
748
Pages

À propos de cet e-book

The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine.

Notes et avis

3,0
1 avis

À propos de l'auteur

After two years of pre-engineering training at the College of Engineering, Seoul National University in Seoul, Korea, the author obtained a scholarship in 1962 to study at the University of Minnesota, Duluth, receiving a Bachelor’s degree in chemistry and mathematics in 1965. The author received a Ph.D. degree in physical organic chemistry from the State University of New York at Albany in 1970. Between 1970 and 74, he was a postdoctoral fellow and a Research Assistant Professor at the Institute for Enzyme Research at the University of Wisconsin, Madison, studying the molecular mechanisms of oxidative phosphorylation in mitochondria. The concept of the conformon that plays a key role in the theory of the living cell described in the book was first formulated while the author was carrying out bio-theoretical research in Madison. He then spent 2 years at the Johnson Research Foundation at the University of Pennsylvania investigating the space-dependent NADH fluorescence signals from rat liver and brains as a function of metabolic and circulatory perturbations. Based on the results of these experiments, the author was invited to join a research group at the Max Planck Institute for Systems Physiology, Dortmund, West Germany, as a visiting scientist, between 1976 and 1979, returning to the US in 1979 as a Research Associate Professor at the Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC. The author spent 3 years in Chapel Hill, elucidating the mechanisms of alcohol-induced liver injury using rat models. Since 1982, the author has been teaching and carrying out theoretical and experimental research in the Department of Pharmacology and Toxicology at Rutgers University, Piscataway, NJ, where the author formulated the Bhopalator model of the cell in 1983 and has been developing and applying it to pharmacology and toxicology ever since.

Donner une note à cet e-book

Dites-nous ce que vous en pensez.

Informations sur la lecture

Smartphones et tablettes
Installez l'application Google Play Livres pour Android et iPad ou iPhone. Elle se synchronise automatiquement avec votre compte et vous permet de lire des livres en ligne ou hors connexion, où que vous soyez.
Ordinateurs portables et de bureau
Vous pouvez écouter les livres audio achetés sur Google Play à l'aide du navigateur Web de votre ordinateur.
Liseuses et autres appareils
Pour lire sur des appareils e-Ink, comme les liseuses Kobo, vous devez télécharger un fichier et le transférer sur l'appareil en question. Suivez les instructions détaillées du Centre d'aide pour transférer les fichiers sur les liseuses compatibles.