OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453 Second edition: Second edition

OECD

sept. 2014 · OECD Series on Testing and Assessment Cartea 116 · OECD Publishing

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This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453. Its objective is to assist users of the TGs to select the most appropriate methodology to assess the chronic toxicity and carcinogenicity of a test chemical so that particular data requirements can be met while reducing animal usage if possible/appropriate.