This special issue collects selected full text peer-reviewed contributions short versions of which were presented at the co-hosting symposium of 5th International Symposium of Gunma University Medical Innovation (GUMI) and 9th International Conference on Advanced Micro-Device Engineering (AMDE), which was held on December 6th, 2018 in Kiryu, Japan, organized by GUMI Promotion Office and Gunma University. The collection covered research results in broad areas in biomedical engineering, applied materials, electrochemistry, nanotechnologies, machinery, signal and data processing, power electronics, and circuit technologies.