The Catecholamines in Psychiatric and Neurologic Disorders

C. Raymond Lake · Michael G. Ziegler

Oct 2013 · Butterworth-Heinemann

About this ebook

The Catecholamines in Psychiatric and Neurologic Disorders focuses on the contributions of catecholamines (CA) in the modulation of blood pressure, stress and exercise, body movements, memory, learning, emotions, thought processing, appetite, and mediation of psychotropic drug action. The selection first elaborates on the techniques for the assessment and interpretation of catecholamine measurements in neuropsychiatric patients and catecholaminergic response to stress and exercise. Discussions focus on noradrenergic response to isometric exercise, isotonic exercise, effect of acceleration on sympathetic activity, techniques for sympathetic nervous system evaluation, and measurements of CA and their metabolites in cerebrospinal fluid. The text then takes a look at urinary CA in behavioral research on stress; CA in anxiety disorders and mitral valve prolapse; and interaction with neurotransmitters in normal subjects and in patients with selected neurologic diseases. The selection examines noradrenergic responses in postural hypotension, norepinephrine, alcohol, and alcoholism, and catecholamine metabolism in anorexia nervosa. Topics include cerebral catecholamine metabolism in anorexia nervosa; central nervous system norepinephrine and voluntary alcohol drinking; and overview of norepinephrine in selected pediatric disorders. The book is a dependable reference for neuropsychiatrists and readers interested in the contributions of catecholamines on psychiatric disorders.

About the author

Dr. Lake graduated with BS and MS degrees in Zoology from Tulane University, New Orleans, LA, in 1965 and 1966. He graduated from Duke University in Durham, NC, School of Medicine with an MD and from the Duke Graduate School (Department of Physiology and Pharmacology) with a Ph.D., in 1971 and 1972. He studied at Oxford University and at St. Bartholomew’s Hospital, London. His residency in Psychiatry was completed at Duke and at the National Institute of Mental Health (NIMH), Bethesda, MD. At Duke he was taught and continues to practice individual, couples and group psychotherapy. At the NIMH, he was privileged to collaborate with and learn about bipolar from Drs. Fred Goodwin, Bob Post, Dennis Murphy, Julie Axelrod and Irv Kopin. He remained in the Laboratory of Clinical Sciences as a research associate, then staff psychiatrist until 1980 when he moved “across the Pike to take a professorship of Psychiatry and Pharmacology at the then new Uniformed Services University of the Health Sciences (USUHS), School of Medicine, Bethesda, MD. He secured two NIH RO1’s, continuing his research on the regulation of the sympathetic nervous system in health and in patients with neuropsychiatric and cardiovascular disorders. He taught medical students and residents in Psychiatry while following patients in his office and clinics. In 1993 he accepted the Chairmanship of Psychiatry at the University of Kansas, School of Medicine, Kansas City, Kansas, and remained Chair for three years after which he continued as Professor on the full-time faculty until his recent partial retirement. As Professor Emeritus he continues to publish about Mood Disorders and to follow his long-term Bipolar patients. Dr. Lake has over 250 journal publications including in Science, Nature, NEJM, AJP and AGP. His book titled Schizophrenia is a Misdiagnosis was published by Springer in 2012. He has achieved distinguished life-fellowship status in the American Psychiatric Association and the American College of Neuropsychopharmacology.