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After the mysterious brutal attack of a local college co-ed, Portland homicide Detective Nick Burkhardt (David Giuntoli) discovered he is descendant of an elite line of criminal profilers known as "Grimms," charged with keeping balance between humanity and the mythological creatures of the world. As he tries to hide the dangers of his new found calling from his fiance, Juliette Silverton (Bitsie Tulloch), and his partner, Hank Griffin (Russell Hornsby), he becomes ever more entrenched in the ancient rivalries and alliances of the Grimm world. With help from his reluctant confidant, Monroe (Silas Weir Mitchell), a reformed Grimm creature himself, Nick must navigate through the forces of a larger-than-life mythology. Reggie Lee and Sasha Roiz also star.