Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime

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MUST WE AGE?
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.

In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

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About the author

Aubrey de Grey, Ph.D., is chairman and chief science officer of the Methuselah Foundation. His major research interests are the role and causes of all forms of cellular and molecular damage in mammalian aging, and the design of interventions to reverse the age-related accumulation of such damage. He has published extensively on these and other areas of gerontology. He is also editor-in-chief of the high-impact journal Rejuvenation Research, the only peer-reviewed academic periodical focusing on intervention in aging. He has formulated a wide-ranging plan for the comprehensive and eventually indefinite postponement of age-related physical and mental decline, named SENS (Strategies for Engineered Negligible Senescence). He is the organizer of an ongoing series of conferences and workshops that focus on the key biomedical research relevant to SENS, and he also oversees the Methuselah Foundation's growing sponsorship of SENS research worldwide.

Michael Rae is Dr. de Grey's research assistant. He is the author of several scientific articles and commentaries in peer-reviewed scientific journals. He is a longtime member and onetime board member of the Calorie Restriction Society, a main contributor to the society's "How-to Guide," and a core scientific investigator with the society's Cohort Study, which seeks to document the feasibility of calorie restriction in humans and the potential human translatability of the anti-aging effects observed in laboratory organisms.

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Additional Information

Publisher
St. Martin's Press
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Published on
Sep 4, 2007
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Pages
400
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ISBN
9781429931830
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Language
English
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Genres
Science / Biotechnology
Technology & Engineering / Biomedical
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Content Protection
This content is DRM protected.
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Available on Android devices
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Eligible for Family Library

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One of the most respected scientists and futurists in America teams up with an expert on human longevity, to show how we can tap today's revolution in biotechnology and nanotechnology to virtually live forever.

Startling discoveries in the areas of genomics, biotechnology, and nanotechnology are occurring every day. The rewards of this research, some of it as spectacular as what was once thought of as science fiction, are practically in our grasp. Already it is possible to analyze our individual genetic makeups and evaluate our predisposition for breast cancer or other deadly diseases on a case-by-case basis. And once we've isolated these genes, the ability to repress or enhance them through biotechnology is just around the corner. Soon, for example, it will be feasible for 10% of our red blood cells to be replaced by artificial cells, radically extending our life expectancy and enhancing our physical and even mental abilities beyond what is humanly possible today. In Fantastic Voyage, Ray Kurzweil and Terry Grossman will show us how amazingly advanced we are in our medical technology, and how incredibly far each of us can go toward living as long as we dare imagine.

With today's mind-bending array of scientific knowledge, it is possible to prevent nearly 90% of the maladies that kill us, including heart disease, cancer, diabetes, kidney disease, and liver disease. Ray Kurzweil and Terry Grossman start the reader on a fantastic journey to undreamed-of vitality with a comprehensive investigation into the cutting-edge science on diet, metabolism, genetics, toxins and detoxification, the hormones involved with aging and youth, exercise, stress reduction, and more. By following their program, which includes such simple recommendations as drinking alkaline water and taking specific nutritional supplements to enhance your immune system and slow the aging process on a cellular level, anyone will be able to immediately add years of healthy, active living to his life.
One of Wall Street Journal’s "Best Books for Science Lovers" in 2015


Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before.

In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility.

Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging.

Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells.

But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young.

The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade.

The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.
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