Drugs And The Older Population

World Scientific
1
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This book is designed for all those with a scientific interest in drug treatment and the older population. The authors have all been chosen for their expertise in the field and have been drawn from both sides of the Atlantic and South Africa. The contents fall into two parts — general principles of drug use as they apply to the elderly, and specific chapters dealing with common clinical areas. The editors aim to provide a concise up to date, evidence-based, resource book./a
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Additional Information

Publisher
World Scientific
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Published on
Jul 12, 2000
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Pages
728
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ISBN
9781783262373
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Language
English
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Genres
Medical / Pharmacology
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Content Protection
This content is DRM protected.
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The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of pharmacovigilance apply to the surveillance of a wide range of medicinal products.

Stephens' Detection and Evaluation of Adverse Drug Reactions provides a comprehensive review of all aspects of adverse drug reactions throughout the life cycle of a medicine, from toxicology and clinical trials through to pharmacovigilance, risk management, and legal and regulatory requirements. It also covers the safety of biotherapeutics and vaccines and includes new chapters on pharmacogenetics, proactive risk management, societal considerations, and the safety of drugs used in oncology and herbal medicines.

This sixth edition of the classic text on drug safety is an authoritative reference text for all those who work in pharmacovigilance or have an interest in adverse drug reactions, whether in regulatory authorities, pharmaceutical companies, or academia.

Praise for previous editions

"This book presents a comprehensive and wide-ranging overview of the science of pharmacovigilance. For those entering or already experienced in the pharmaceutical sciences, this is an essential work.” - from a review in E-STREAMS

"...a key text in the area of pharmacovigilance...extensively referenced and well-written...a valuable resource..." - from a review in The Pharmaceutical Journal

Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This unique book, Discoveries in Pharmacological Sciences, contains the history of herbal medicine as it emerged about 5,000 years ago. Recent discoveries in genetics are integrated with the observations in the past. An understanding of the history of drugs and toxic chemicals is essential for the proper utility of these substances by the population at large. The book is written with the purpose to familiarize drug research of the investigators in chemical, pharmaceutical, pharmacological, and biomedical sciences. It is important to note that plants containing morphine, quinine, physostigmine, pilocarpine, atropine, d-tubocurarine, reserpine, tetrahydrocannabinol, cardiac glycosides, ephedrine and colchicine were used by various cultures for centuries. Since 1805 pure, active, therapeutic constituents were isolated and chemically characterized. Parallel to these developments, the science of human anatomy, physiology, biochemistry, genetics and pharmacology has advanced. New synthetic drugs were discovered. The chemistry of perfumes and sensory functions including memory were elucidated. The history of fascinating discoveries made by scientists of Nobel repute was documented. Better testing methods were developed. The causes of many diseases were better understood. Drug laws were instituted a century ago. The pharmaceutical industry flourished. The text provides a panoramic view of the understanding of when, where, who, how and why drugs were developed. Educational aspects of teaching pharmacological sciences are reviewed. The historical account will be invaluable to graduate students and creative scientists, who can prepare for the future.The book will serve to enhance the cumulative scientific knowledge of the investigators in drug discovery. It contains a well integrated wealth of information in drug sciences and pharmacotherapeutics. The time, place and the human side of investigators, their portraits with biographical sketches are presented.The reading of Discoveries in Pharmacological Sciences will satisfy the intellectual curiosity of investigators. Understanding of Discoveries in Pharmacological Sciences will provide a platform to judge the importance of the personalized medicine of tomorrow. Scattered classical information about drug sciences is effectively condensed here. The development of the scientific thoughts and creativity of the investigators through the ages in drug research are presented admirably.
This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs -- the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies.

The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe.

Contents: Human Arylamine N-acetyltransferases (NATs)Drug Metabolism & Pharmacogenetics Then and NowHuman NAT2: Phenotypic Correlation with Genotype, Clinical PerspectiveHuman NAT2: Genomics for NAT2 PolymorphismsHuman NAT1NAT in OntogenyNATs in TissuesNATs in AnthropologyNATs in Other Eukaryotic OrganismNATs in Primates and in EvolutionTransgenic AnimalsFungal NATsNATs in Prokaryotic OrganismsBacterial NATsMycobacterial NATsNAT and DiseasesHuman NAT2 in Cancer PredictionHuman NAT1 and Breast CancerMycobacterial NATs and TuberculosisNAT Nomenclature
Readership: Biotechnology & pharmaceutical industry professionals, graduate students and researchers in cell biology, biochemistry and genetics; clinicians; senior undergraduates in cell biology, biochemistry and genetics; toxicologists, pharmacologists and those with an interest in drug and xenobiotic metabolism; evolutionary biologists and genetic anthropologists.
Keywords: Pharmacogenetics;Toxicity;Cancer;Tuberculosis;Arylamine;Isoniazid;Drug Metabolism;XenobioticsReview: Key Features: The book features all of the key figures in the field of the arylamine N-acetyltransferases and includes scientists from Australia, Canada, France, Germany, Greece, Italy, Jordan, Spain, Switzerland, the United Kingdom, and the United StatesThe treatment including human isoenzymes and also the NAT enzymes from other organisms makes a unique contribution. The coverage is from basic chemistry in identifying NAT substrates and inhibitors to anthropological studies of pharmacogenetics and also studies on fungi where the possibilities for commercial exploitation of these enzymes are ripe for investigationEach chapter is designed to be stand alone as well as fitting into an overall framework
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