Stephens' Detection and Evaluation of Adverse Drug Reactions provides a comprehensive review of all aspects of adverse drug reactions throughout the life cycle of a medicine, from toxicology and clinical trials through to pharmacovigilance, risk management, and legal and regulatory requirements. It also covers the safety of biotherapeutics and vaccines and includes new chapters on pharmacogenetics, proactive risk management, societal considerations, and the safety of drugs used in oncology and herbal medicines.
This sixth edition of the classic text on drug safety is an authoritative reference text for all those who work in pharmacovigilance or have an interest in adverse drug reactions, whether in regulatory authorities, pharmaceutical companies, or academia.
Praise for previous editions
"This book presents a comprehensive and wide-ranging overview of the science of pharmacovigilance. For those entering or already experienced in the pharmaceutical sciences, this is an essential work.” - from a review in E-STREAMS
"...a key text in the area of pharmacovigilance...extensively referenced and well-written...a valuable resource..." - from a review in The Pharmaceutical Journal
The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe.Contents: Human Arylamine N-acetyltransferases (NATs)Drug Metabolism & Pharmacogenetics Then and NowHuman NAT2: Phenotypic Correlation with Genotype, Clinical PerspectiveHuman NAT2: Genomics for NAT2 PolymorphismsHuman NAT1NAT in OntogenyNATs in TissuesNATs in AnthropologyNATs in Other Eukaryotic OrganismNATs in Primates and in EvolutionTransgenic AnimalsFungal NATsNATs in Prokaryotic OrganismsBacterial NATsMycobacterial NATsNAT and DiseasesHuman NAT2 in Cancer PredictionHuman NAT1 and Breast CancerMycobacterial NATs and TuberculosisNAT Nomenclature