Design and Analysis of Cross-Over Trials: Edition 3

Byron Jones · Michael G. Kenward

tet 2014 · CRC Press

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Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture.T

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Byron Jones is a senior biometrical fellow and executive director in the Statistical Methodology Group at Novartis Pharmaceuticals. Previously he was a senior statistical consultant/senior director at Pfizer and a senior director and UK head of the Research Statistics Unit at GlaxoSmithKline. In addition to 14 years of experience in the pharmaceutical industry, he has 25 years of experience in academia, ultimately holding the position of professor of medical statistics at De Montfort University. Currently he is an honorary professor at the London School of Hygiene and Tropical Medicine, visiting professor at University College London and at the University of Leicester, and a visiting professorial fellow at Queen Mary, University of London.

Michael G. Kenward is GlaxoSmithKline professor of biostatistics at the London School of Hygiene and Tropical Medicine. Previously he held positions at the Universities of Kent and Reading in the UK, and at research institutes in the UK, Iceland, and Finland. He has acted as a pharmaceutical industry consultant in biostatistics for more than 25 years. His research interests include the analysis of longitudinal data and cross-over trials, and modeling in biostatistics, with a particular interest in the problem of missing data. He has co-authored three textbooks and is well known for his 1994 Royal Statistical Society read paper on missing data.