Diabetes: Chapter 6. Iron, Oxidative Stress and Diabetes

·
· Elsevier Inc. Chapters
Liburu elektronikoa
280
orri
Egokia

Liburu elektroniko honi buruz

Iron is a micronutrient which exists in the redox states Fe2+ and Fe3+. The easy transition between the two contributes to its metabolic functions and toxic effects. Iron is normally sequestered by binding to proteins – hemoproteins and non-heme iron proteins. Iron homeostasis is maintained by regulation at the levels of dietary uptake and gene expression of iron binding proteins – transferrin receptor and ferritin, to prevent the release of catalytically active Fe2+ ions. Free iron promotes oxidative stress by generating highly reactive hydroxyl radicals through the Fenton/Haber Weiss reactions, which react with cellular biomolecules, resulting in tissue damage. Diabetes is a metabolic disorder characterized by hyperglycemia and oxidative stress. The elevated iron levels in diabetes also elicit oxidative stress and probably mediate insulin deficiency, insulin resistance, hepatic dysfunction and decreased antioxidant defense systems. Both iron overload and deficiency enhance oxidative stress and promote the prognosis of diabetes and its complications.

Baloratu liburu elektroniko hau

Eman iezaguzu iritzia.

Irakurtzeko informazioa

Telefono adimendunak eta tabletak
Instalatu Android eta iPad/iPhone gailuetarako Google Play Liburuak aplikazioa. Zure kontuarekin automatikoki sinkronizatzen da, eta konexioarekin nahiz gabe irakurri ahal izango dituzu liburuak, edonon zaudela ere.
Ordenagailu eramangarriak eta mahaigainekoak
Google Play-n erositako audio-liburuak entzuteko aukera ematen du ordenagailuko web-arakatzailearen bidez.
Irakurgailu elektronikoak eta bestelako gailuak
Tinta elektronikoa duten gailuetan (adibidez, Kobo-ko irakurgailu elektronikoak) liburuak irakurtzeko, fitxategi bat deskargatu beharko duzu, eta hura gailura transferitu. Jarraitu laguntza-zentroko argibide xehatuei fitxategiak irakurgailu elektroniko bateragarrietara transferitzeko.