This manual, published by the World Health Organization, provides comprehensive guidance on the eradication of yaws, focusing on surveillance, monitoring, and evaluation. It serves as a resource for yaws eradication program managers and outlines strategies for detecting and confirming cases, data collection, and dissemination. The manual covers essential topics such as the criteria for interrupting yaws transmission, mapping of endemic areas, and the evaluation of community treatment phases. It aims to equip health professionals with the necessary tools and frameworks to achieve successful eradication of yaws, a neglected tropical disease. The intended audience includes public health officials, program managers, and health workers involved in disease eradication efforts.