Biochemical Actions of Hormones V12: Volume 12

Gerald Litwack

Dec 2012 · Elsevier

About this ebook

Biochemical Actions of Hormones, Volume XII is a compendium of papers discussing aspects of molecular biology with regard to hormone action and to certain hormone receptors. One paper discusses the different approaches and strategies that are used in determining the amino acid sequence. The paper also describes the structural organization of polyprotein precursors such as the peptide chemistry approach or the nucleic acid approach. Another paper investigates the regulation of prolactin biosynthesis by peptide hormones as a model for peptidergic regulation of gene expression. The paper defines in detail which components of the biosynthetic machinery are being regulated by the polypeptide hormones. One paper also analyzes the molecular biology of the metallothioneins, focusing on the glucocorticoid regulation of metallothioneins genes. Experiments show that when the mouse MT-I gene is activated in lymphoid cells, or transferred to other cells, it still retains information needed in metal-regulated expression, though glucocorticoids can no longer regulate the same gene. Other papers discuss the purification and properties of the nerve growth factor receptor, and the thyrotropin receptor. Micro-biologists, biochemists, molecular biologists, cellular biologists, endocrinologists, and scientists involved in cell research will find this collection valuable.

About the author

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.