This World Health Organization (WHO) guidance document provides strategic leadership advice for Heads of WHO Country Offices (HWCOs) serving as Cluster Lead Agency (CLA) for health within the Inter-Agency Standing Committee (IASC) framework. It outlines the responsibilities and accountabilities of HWCOs in coordinating health clusters during humanitarian emergencies. The document emphasizes the coordination of health actors, cluster activation and deactivation protocols, and strategic planning to ensure effective health response. It aims to enhance WHO's capacity to manage large-scale humanitarian operations and improve service delivery to affected populations. The guidance is designed for WHO country office heads, humanitarian coordinators, and national health authorities.