About this ebook
Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.
About the author
Dr. Henry Lynch was born on July 4, 1928, in Lawrence, Mass. He grew up on the Upper West Side of Manhattan. He studied medicine and became the dioctor who found the hereditary link in cancer. He began his research by traveling to gatherings of families that he suspected had histories of hereditary cancer. He met family members and asked: Who in the family had cancer? What kind of cancer? Could he get medical records, and blood samples, which he could freeze and store? He hand-drew family trees, with squares for men and circles for women, marking who got cancer and what kind. He was soon insisting to a doubting world that he had found evidence of genetic links. In time, the medical world accepted his claims, and his work- the family trees, the blood samples eventually contributed to the discovery, by others, of a gene that when mutated can lead to colon cancer and an array of other cancers. He also contributed work that led to the discovery of gene mutations that greatly increase the risk of breast and ovarian cancer.One form of hereditary cancer is often called Lynch syndrome (it is also known as hereditary non-polyposis colorectal cancer, or HNPCC) because Dr. Lynch first identified families in which it occurs. People with Lynch syndrome have a higher risk of certain types of cancer. On Jun 2, 2019 Dr. Lynch passed away of congestive heart failure at Bergen Mercy Hospital at the age of 91.
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