Methods for Assessing the Adherence to Medical Devices

Leah M. Johnson · Stephanie L. Swarner · Ariane van der Straten · Ginger D. Rothrock

aug 2016 · RTI Press

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The assessment of patient adherence to medication is necessary to distinguish between nonadherence and inferior drug efficacy, which is crucial for avoiding poor clinical outcomes. Adherence measurements pose various challenges, as many methods rely on subjective assessments or slow and costly measurements, which are infeasible in resource-poor settings. Recent developments of new medical devices for delivery of medications requires additional considerations in terms of adherence. In this report, we propose that medical devices may serve a dual-functional purpose: deliver drug and monitor adherence. We provide an illustrative case study that involves assessing the adherence of vaginal rings for delivery of antiretroviral drugs for pre-exposure prophylaxis (PrEP) of HIV.

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PhD, is a research chemist at RTI International, where she leads a variety of research and development projects involving advanced materials for applications in both the health and the energy industries.  

BS, is a materials engineer at RTI International. She develops polymeric materials for a variety of medical device technologies.

PhD, MPH, is an RTI Fellow and director of the Women’s Global Health Imperative group. She is a global leader in investigating the acceptability of and adherence to new biomedical technologies for HIV prevention.

PhD, is the director of the Advanced Materials and Systems Integration group at RTI. She is responsible for business development and technical leadership in the areas of advanced materials and manufacturing for commercial sectors.