Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

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This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike.

The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result.

The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.

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About the author

Michael W. Jann, Pharm.D., FCP, FCCP is Professor and Chair for the Department of Pharmacotherapy at the University of North Texas System College of Pharmacy (UNTSCP) located at the UNT Health Sciences Center (UNTHSC). Professor Jann received his Doctor of Pharmacy degree from the University of Southern California and post-doctoral training in mental health pharmacy practice at the University of Tennessee Memphis College of Pharmacy. He has published over 230 peer-review articles, abstracts, and book chapters and served as a primary investigator for numerous clinical trials in psychopharmacology. Professor Jann serves on the editorial boards of six peer-review scientific journals including CNS Drugs, Molecular Diagnostics and Therapeutics, The Scientific World Journal – Pharmacology Section, The Consultant Pharmacist, Journal of Clinical Pharmacology, and Journal of Pharmacy Practice.

Scott R. Penzak, Pharm.D., FCP, is Professor and Vice Chair for the Department of Pharmacotherapy at the University of North Texas System College of Pharmacy (UNTSCP) located at the UNT Health Sciences Center (UNTHSC). Professor Penzak received his Doctor of Pharmacy degree from Wayne State University and completed his post-doctoral training in infectious diseases at the University of Arkansas for Medical Science (UAMS). Prior to UNTSCP, he was the Director of the Clinical Pharmacokinetics Laboratory at the NIH. He has published over 150 peer-review articles, abstracts, and book chapters, and served as a principal investigator on numerous pharmacokinetic and pharmacogeneticstudies. Professor Penzak serves on the editorial boards of three peer-review scientific journals including Journal of Clinical Pharmacology, Pharmacotherapy, and the International Journal of Pharmacokinetics.

Lawrence J. Cohen, PharmD, BCPP, FASHP, FCCP, FCP, FNAP is currently Professor of Pharmacotherapy at the University of North Texas System College of Pharmacy. Examples of Professor Cohen’s previous service include, Global Director of CNS Research for Kendle International, Director of the Office of Clinical Trials for University of Cincinnati, and Director of Pharmaceutical Services for the Oklahoma Department of Mental Health and Substance Abuse Services. Professor Cohen received his Doctor of Pharmacy degree and post-doctoral training in psychiatric pharmacy from University of Southern California School of Pharmacy. Professor Cohen has been a Board Certified Psychiatry Pharmacist since the specialty was recognized. His relevant service on Editorial Boards include Current Psychiatry, Innovations in Clinical Neuroscience, Primary Care Companion of the Journal of Clinical Psychiatry, Drug Benefit Trends, Journal of the American Medical Directors Association, CNS News and Pharmacy Practice News.

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Additional Information

Publisher
Springer
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Published on
Mar 2, 2016
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Pages
601
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ISBN
9783319278834
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Language
English
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Genres
Medical / Pharmacology
Medical / Pharmacy
Medical / Psychiatry / Psychopharmacology
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Content Protection
This content is DRM protected.
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Volume 18 of the Handbook of Psychopharmacology represents the first of a series of volumes intended to bring earlier sections of the work up to date. Volumes 7, 8, and 9, published in 1977 and 1978, dealt with principles of behavior, drugs and neurotransmitters, and neuroanatomy. In subsequent volumes dedicated to these issues, a mixture of topics will be covered in a given volume, covering both advances in basic knowledge in these three areas of the subject and reviews of theoretical and meth odological issues deemed to be of particular relevance at present. L. L. !. S. D. !. S. H. S. vii CONTENTS CHAPTER 1 Behavior as a Measure of Adverse Responses to Environmental Contaminants BERNARD WEISS 1. Special Perspectives 1 1. 1. Pharmacology and Toxicology . . . . . . . . . . . . . . 1 1. 2. Origins of Behavioral Toxicology . . . . . . . . . . . . 2 1. 3. Special Problems 2 2. Specific Substances . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 1. Heavy Metals 5 2. 2. Volatile Solvents 20 2. 3. Pesticides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 2. 4. Air Pollutants 36 2. 5. Nonspecific Poisons . . . . . . . . . . . . . . . . . . . . . . 42 2. 6. Food Additives 44 3. Future Prospects 47 3. 1. Chemical Waste . . . . . . . . . . . . . . . . . . . . . . . . . 47 3. 2. Susceptible Populations . . . . 48 3. 3. The Statistics of Risk . . . . . . . . . . . . . . . . . . . . . 49 3. 4. Screening 49 3. 5. Implications for Psychopharmacology 51 4. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 CHAPTER 2 State Dependent Learning and Drug Discriminations DONALD A. OVERTON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 2. Description of State Dependent Learning . . . . . . . . . . 59 ix x CONTENTS 3. History of Development of Knowledge about SDL 60 3. 1. Nineteenth Century Reports. . . . . . . . . . . . . . . .
Parents have heard that play is a child's work—but play is not for kids only. As psychologist Lawrence J. Cohen, Ph.D., demonstrates in this delightful new book, play can be the basis for an innovative and rewarding approach to parenting. From eliciting a giggle during baby's first game of peek-a-boo to cracking jokes with a teenager while hanging out at the mall, Playful Parenting is a complete guide to using play to raise strong, confident children.

Have you ever stepped back to watch what really goes on when your children play? As Dr. Cohen points out, play is children's complex and fluid way of exploring the world, communicating hard-to-express feelings, getting close to those they care about, working through stressful situations, and simply blowing off steam. That's why "playful parenting" is so important and so successful in building strong, close bonds between parents and children. Through play we join our kids in their world. We help them express and understand deep emotions, foster connection, aid the process of emotional healing--and have a great time ourselves while we're at it.

Anyone can be a playful parent--all it takes is a sense of adventure and a willingness to let down your guard and try something new. After identifying why it can be hard for adults to play, Dr. Cohen discusses how to get down on the floor and join children on their own terms. He covers games, activities, and playful interactions that parents can enjoy with children of all ages, whether it's gazing deep into a baby's eyes, playing chase with a toddler, fantasy play with a grade schooler, or reducing a totally cool teenager to helpless laughter.

Playful Parenting also includes illuminating chapters on how to use play to build a child's confidence and self-esteem, how to play through sibling rivalry, and how play can become a part of loving discipline. Written with love and humor, brimming with good advice and revealing anecdotes, and grounded in the latest research, Playful Parenting will make you laugh even as it makes you wise in the ways of being a happy, effective, enthusiastic parent.
A clinical psychiatrist explores the effects of DMT, one of the most powerful psychedelics known.

• A behind-the-scenes look at the cutting edge of psychedelic research.

• Provides a unique scientific explanation for the phenomenon of alien abduction experiences.

From 1990 to 1995 Dr. Rick Strassman conducted U.S. Government-approved and funded clinical research at the University of New Mexico in which he injected sixty volunteers with DMT, one of the most powerful psychedelics known. His detailed account of those sessions is an extraordinarily riveting inquiry into the nature of the human mind and the therapeutic potential of psychedelics. DMT, a plant-derived chemical found in the psychedelic Amazon brew, ayahuasca, is also manufactured by the human brain. In Strassman's volunteers, it consistently produced near-death and mystical experiences. Many reported convincing encounters with intelligent nonhuman presences, aliens, angels, and spirits. Nearly all felt that the sessions were among the most profound experiences of their lives.

Strassman's research connects DMT with the pineal gland, considered by Hindus to be the site of the seventh chakra and by Rene Descartes to be the seat of the soul. DMT: The Spirit Molecule makes the bold case that DMT, naturally released by the pineal gland, facilitates the soul's movement in and out of the body and is an integral part of the birth and death experiences, as well as the highest states of meditation and even sexual transcendence. Strassman also believes that "alien abduction experiences" are brought on by accidental releases of DMT. If used wisely, DMT could trigger a period of remarkable progress in the scientific exploration of the most mystical regions of the human mind and soul.
“The most helpful book on childhood anxiety I have ever read.”—Michael Thompson, Ph.D.
 
Whether it’s the monster in the closet or the fear that arises from new social situations, school, or sports, anxiety can be especially challenging and maddening for children. And since anxiety has a mind of its own, logic and reassurance often fail, leaving parents increasingly frustrated about how to help. Now Lawrence J. Cohen, Ph.D., the author of Playful Parenting, provides a special set of tools to handle childhood anxiety. Offering simple, effective strategies that build connection through fun, play, and empathy, Dr. Cohen helps parents
 
• start from a place of warmth, compassion, and understanding
• teach children the basics of the body’s “security system”: alert, alarm, assessment, and all clear.
• promote tolerance of uncertainty and discomfort by finding the balance between outright avoidance and “white-knuckling” through a fear
• find lighthearted ways to release tension in the moment, labeling stressful emotions on a child-friendly scale
• tackle their own anxieties so they can stay calm when a child is distressed
• bring children out of their anxious thoughts and into their bodies by using relaxation, breathing, writing, drawing, and playful roughhousing
 
With this insightful resource of easy-to-implement solutions and strategies, you and your child can experience the opposite of worry, anxiety, and fear and embrace connection, trust, and joy.
 
Praise for The Opposite of Worry
 
“The Opposite of Worry is an informative resource for parents and other family members. The book is easy to read, comprehensive and notable for its many practical suggestions.”—New England Psychologist

“Good advice for parents making daily calls to the pediatrician . . . Anxiety is a full-body sport, and Cohen’s main advice is not to treat it with words but with actions. . . . Physicality is about living in the present, and for anxious people, the present is a powerful place of healing. Intended for parents of children ages 3 to 15, this book offers anecdotes and fun anti-anxiety games.”—Publishers Weekly
 
“Here’s the help parents of anxious children have been looking for! Dr. Cohen’s genius is in the warm and generous spirit of the strategies he outlines for parents. He grounds his playful approach in a sound explanation of how anxiety affects children, and how they heal. Parents will come away with plenty of ideas to help them develop their children’s confidence. While reading, I found myself thinking, ‘I’d like to try that for myself!’”—Patty Wipfler, founder and program director, Hand in Hand Parenting
 
“If you want to understand your child’s anxiety—and your own parental worries—you must read Larry Cohen’s brilliant book, The Opposite of Worry. Dr. Cohen is one of the most imaginative and thoughtful psychologists you will ever encounter. He explains how and why children become anxious and then shows how we can use empathy and play to help them escape from the terrifying dark corners of childhood.”—Michael Thompson, Ph.D.
 
“The Opposite of Worry offers a treasure trove of ideas to help children feel confident and secure. Lawrence Cohen has written a book that will help every parent of an anxious child.”—Aletha Solter, Ph.D., founder, Aware Parenting, and author of Attachment Play
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