Molecular Biology: A Selection of Papers

Sydney Brenner

Des. 2012 · Academic Press

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Founded in 1959, by John Kendrew, the Journal of Molecular Biology was the first journal devoted to this new and revolutionary science. To celebrate the thirtieth anniversary of the Journal, the current editor, Sydney Brenner, has selected a number of papers from the first hundred volumes. They include the seminal papers on genetic regulation by Jacob and Monod and on allostery by Monod, Changeux and Jacob. Also included are many important papers on structural biology and molecular genetics and papers reflecting the initial developments in DNA cloning and sequencing.
Of value to all biologists with an interest in the molecular basis of living systems, the book is a personal selection by the Editor. Readers are encouraged to compare it with their own choice from the Journal of Molecular Biology.

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Sydney Brenner was born in Germiston, South Africa on January 13, 1927. He studied medicine at the University of the Witwatersrand in Johannesburg. After finishing medical school in 1951, he won a scholarship to Oxford to work on bacteriophages, the viruses that attack bacteria. A few years later, he took a post at the Medical Research Council Laboratory of Molecular Biology at Cambridge and stayed there for 20 years. Brenner helped determine the nature of the genetic code by conducting a series of experiments in which he altered the DNA of a virus that attacks bacteria. He shared a Nobel Prize with John Sulston and H. Robert Horvitz in 2002 for developing a tiny transparent worm into a test bed for biological discoveries. Brenner also received the Lasker Award in medical science in 1971. From 1994 to 2000 he wrote an opinion column for the journal Current Biology. His autobiography, My Life in Science, was published in 2001. He died on April 5, 2019 at the age of 92.