Nanocarriers for Organ-Specific and Localized Drug Delivery

Muhammad Raza Shah · Muhammad Imran Malik · Shafi Ullah

Apr 2022 · Elsevier

About this ebook

Organ-specific drug delivery is aimed at achieving increased concentration of therapeutic molecules at target sites with minimum side effects on other healthy tissues. Similarly, drug-specific delivery to some vital organs, such as the brain, lungs, heart and kidneys remains a challenging task for the formulation scientists. Oral delivery of most of the commercially available life-saving drugs has also been impeded by various physio-chemical and biological barriers. These advancements in nanotechnology have led to the development of various pharmaceutical nanocarriers.Nanocarriers for Organ-Specific and Localized Drug Delivery summarizes targeted drug delivery systems and approaches to the major organs of the body. The book shows how drugs can be specifically targeted to the pathological area within an organ in a viable way. Employing pharmaceutical nanocarriers for drug delivery targeted to specific organs of the body requires a comprehensive knowledge of the disease site's pathophysiology as well as physical, chemical and pharmaceutical techniques for modification or functionalization of the nanocarriers.Combining theoretical principles and practical applications of various nanocarriers for organ-specific drug delivery, this is an important reference source for all those seeking to increase their understanding of how pharmaceutical nanocarriers are being used to create more efficient drug delivery systems. - Outlines the underlying principles for the design of advanced pharmaceutical nanocarriers for organ specific drug delivery - Includes guidance on how to exploit the pathophysiology and microenvironment of the diseased sites for targeted drug delivery - Assesses the major challenges for creating pharmaceutical nanocarriers on a mass scale

About the author

Muhammad Raza Shah is a full professor at the International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research. He is a recipient of several awards, including the Tamgha-i-Imtiaz Award from the President of Pakistan, the Salam Prize, the Professor Atta ur Rahman Gold Medal, and the Dr M Raziuddin Siddiqi Prize, by the Pakistan Academy of Sciences, for scientists under 40 years of age, in the field of chemistry. Professor Shah has authored six books and edited four books, in addition to contributing over 350 peer-reviewed journal papers. One of his authored books was declared as best book of 2017 by the Government of Pakistan's Higher Education Commission.Dr. Muhammad Imran Malik is an Associate Professor at the HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Pakistan. He received his doctorate in polymer chemistry at Karl-Franzens-Universitäte, Graz, Austria, in 2009, and subsequently worked as a post-doctoral research scientist, at the University of Stellenbosch, South Africa, and at POSTECH, in South Korea, with his research focusing on analytical polymer science. In 2012, he joined the International Center of Chemical and Biological Sciences at the University of Karachi as an Assistant Professor. Dr. Malik's main research interests are the synthesis of novel polymeric architectures and the development of comprehensive analytical methods for polymers, as well as polymer-stabilized nanoparticles and their applications, such as sensors, drug delivery, molecularly imprinted polymers, and organic solar cells.Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.