Common Cold

Springer Science & Business Media
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The common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is one of the most complex diseases because of the number of viruses that cause the familiar syndrome of sneezing, sore throat, runny nose and nasal congestion. These two factors have made a ‘cure’ for the common cold one of the most difficult scientific and clinical endeavours (a topic often d- cussed in the popular media, where comparisons are made with the ease of putting a man on the moon). The present book brings together a wide range of experts from epidemiologists to virologists and pharmacologists to look at recent advances in our knowledge of the common cold. In some respects the book is unique, as it focuses on the common cold, a syndrome so familiar to the layperson but one that receives little attention from the scientist and clinician. The common cold can be viewed from many different aspects as illustrated in Figure 1. The core knowledge for understanding the common cold must first come from virology and this is discussed in several chapters of the book. There have been major advances in this field because of the use of new methods of detecting viruses such as polymerase chain reaction techniques that have greatly aided our understanding of the epidemiology of viruses associated with common cold.
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Additional Information

Publisher
Springer Science & Business Media
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Published on
Nov 16, 2009
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Pages
358
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ISBN
9783764399122
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Language
English
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Genres
Medical / General
Medical / Microbiology
Medical / Research
Science / Life Sciences / Molecular Biology
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Content Protection
This content is DRM protected.
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The study of poxviruses has a long and distinguished history that includes Jenner’s founding work on smallpox vaccination. In the more than 200 years since that time we have seen the remarkable eradication of smallpox. It is difficult to overstate the significance of that achievement. It not only removed a disease that must rate as one of humankind’s greatest scourges, but also demonstrated the effectiveness of the general principle of vacci- tion in our battles against disease. This book begins with a review of smallpox and its causative agent, Variola virus. The vaccine used in the successful smallpox eradication c- paign, vaccinia virus, is reviewed in the following chapter that describes its origin and its use as a vaccine, as well as the current understanding of the molecular biology and pathogenesis of this virus. Vaccinia virus is the most intensively studied poxvirus and the descriptions of the biology of this virus are relevant to all vertebrate poxviruses. The eradication of smallpox has drawn attention to the potential threat posed by other orthopoxviruses that infect humans, particularly Monkeypox virus. A description of this virus is given in the third chapter. Jenner’s ori- nal vaccine is believed to have been Cowpox virus and this virus is reviewed in the chapter by Essbauer and Meyer. Additional chapters are devoted to each of the recognized genera of the vertebrate poxviruses and a f- ther chapter describes the subfamily of poxviruses infecting invertebrates. Together these provide a comprehensive review of the poxvirus family.
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