The WHO BioHub System document outlines the criteria and operational modalities for biosafety and biosecurity in laboratories participating in the international exchange of biological materials. It aims to enhance global preparedness and response to epidemic and pandemic diseases by ensuring timely sharing of biological samples. Laboratories must meet WHO's biosafety and biosecurity standards to qualify as a Qualified Entity. The document covers a range of requirements such as risk assessment, emergency response, inventory control, and training programs. It is intended for laboratories and institutions involved in handling potentially harmful biological agents, offering guidelines to maintain safety and security.