This WHO operational handbook on tuberculosis focuses on prevention, specifically tuberculosis preventive treatment. Published by the World Health Organization in 2020, it provides comprehensive guidelines for implementing TB preventive treatment, outlining strategies to prevent the development of tuberculosis in high-risk populations. The handbook covers critical topics such as screening and testing for TB infection, ruling out TB disease before treatment, managing adverse reactions, and ensuring adherence to treatment protocols. It also addresses ethical considerations and offers tools for monitoring and evaluation. The handbook is intended for healthcare professionals and policymakers involved in TB prevention and control, offering evidence-based recommendations and insights from global experts.