Chronopharmaceutics: Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

Bi-Botti C. Youan

Aug 2009 · Sold by John Wiley & Sons

About this ebook

Chronopharmaceutics

Science and Technology for Biological Rhythm Guided Therapy and Prevention of Diseases

Edited by

Bi-Botti C. Youan

The first standard reference on chronopharmaceutics

As we better understand how biological processes unfold in real time through advances in chronobiology and related fields, we can create safer, more effective drugs, drug delivery systems, and disease monitoring and prevention systems. When administered in correct coordination with a patient's body rhythms, such drugs can maximize therapeutic outcome while minimizing unwanted side effects. Chronopharmaceutics presents the first standard reference text on this emerging cross-disciplinary field and its potential for therapeutic and preventive medicine.

Bringing together the latest findings from experienced investigators, this edited work presents a much-needed single source on chronopharmaceutics. After an introduction that includes a timeline of key discoveries, an overview of regula-tory, formulation, manufacturing and key resource issues associated with chronopharmaceutics, the detailed coverage examines:

• Chronogenetics

• Chronopharmacokinetics

• Chronotherapy

• Controlled release systems triggered by physical and/or chemical activation

• Chronopharmacodynamics, chronomics, and anesthesia

• Markers-guided chronotheranostics

Filling a gap in both the graduate classroom and the working industrial or research laboratory, Chronopharmaceutics offers students, instructors, and professionals a unique and comprehensive reference for this cutting-edge field.

Ratings and reviews

This resource, no doubt, is an excellent addition to the library in any college of pharmacy. It draws clinicians attention to the critical but often neglected impact of biological rythm-guided timing of drug delivery to the site of action on its pharmacodynamics. More than mean residence time (MRT), I think dosage form design scientists, pharmacokinetists and clinicians need to recognize and apply more effectively the factor of biological rythm-guided dose timing to the optimization of therapeutic outcome in disease management. In order to promote the concept of chronopharmaceutics and chronotherapeutics in this book to our Pharm. D students, I would like to request one personal copy and another copy to the Library at the Roosevelt College of Pharmacy at 1400 N Roosevelt Boulevard in Schaumburg, IL60173. Both copies could be sent to the same address, Attention: Dr. Amusa S. Adebayo. Thank you.

About the author

Bi-Botti C. Youan, PharmD, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri Kansas City School of Pharmacy. He is on the editorial board of the Journal of Environmental Pollution; and a member of the Controlled Release Society, the American Chemical Society, and the American Association of Pharmaceutical Scientists (AAPS). Dr. Youan initiated the first AAPS Sunrise School on Chronopharmaceutical Drug Delivery in 2004. He earned his doctorate from the Université Catholique de Louvain, Brussels, Belgium.