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Mayelana nalolu hlelo lokusebenza

I-OnADose iyithuluzi le-onabotulinumtoxinA lokudosa kanye nokusungula kabusha abahlinzeki bezempilo base-US. Uhlelo lokusebenza luvumela odokotela ukuthi benze izibalo zokudosa eziqondile ze-spasticity, i-dystonia yomlomo wesibeletho, kanye ne-migraine engapheli.

I-OnabotulinumtoxinUlwazi Olubalulekile Lokuphepha

Izinkomba ze-Onabotulinumtoxin

I-Migraine Engapheli
-OnabotulinumtoxinA iboniswa ukuvimbela ubuhlungu bekhanda ezigulini ezikhulile ezine-Chronic Migraine (≥ izinsuku ezingu-15 ngenyanga ezinekhanda elibuhlungu elihlala amahora angu-4 ngosuku noma ngaphezulu).
Imikhawulo Yokusebenzisa
-Ukuphepha nokusebenza kahle akukasungulwa ukuze kuvinjelwe i-episodic migraine (izinsuku zekhanda le-14 noma ezimbalwa ngenyanga) ezifundweni ezilawulwa yi-7 placebo.

I-Spasticity
I-OnabotulinumtoxinA iboniswa ekwelapheni i-spasticity ezigulini ezineminyaka emi-2 nangaphezulu.
Imikhawulo Yokusebenzisa
-I-OnabotulinumtoxinA ayizange iboniswe ukuthuthukisa amakhono okusebenza onqenqemeni olungaphezulu noma uhla lokunyakaza kwilunga elithintekile isivumelwano esimisiwe.

I-Cervical Dystonia
-I-OnabotulinumtoxinA iboniswa ukwelashwa kwabantu abadala abane-Cervical Dystonia ukuze kuncishiswe ubunzima besimo esingavamile sekhanda kanye nobuhlungu bentamo obuhambisana neCervical Dystonia.

ULWAZI OLUBALULEKILE LOKUPHEPHA, KUHLANGANISA ISEXWAYISO SESIBHOKISI

ISEXWAYISO: UKUSAKAZA KUDE KOMPHUMELA WOBUTHINI

Imibiko ye-Postmarketing ibonisa ukuthi imiphumela ye-onabotulinumtoxinA nayo yonke imikhiqizo yobuthi be-botulinum ingase isakazeke isuka endaweni yomjovo ukuze iveze izimpawu ezihambisana nemiphumela yobuthi be-botulinum. Lokhu kungase kuhlanganise i-asthenia, ubuthakathaka obujwayelekile bemisipha, i-diplopia, i-ptosis, i-dysphagia, i-dysphonia, i-dysarthria, ukungakwazi ukuzibamba komchamo kanye nobunzima bokuphefumula. Lezi zimpawu ziye zabikwa emahoreni kuya emavikini ngemva kokujova. Ubunzima bokugwinya nokuphefumula bungaba yingozi empilweni futhi kube nemibiko yokufa. Ubungozi bezimpawu bukhulu kakhulu ezinganeni ezilashelwa i-spasticity kodwa izimpawu zingase zenzeke nakubantu abadala abalashelwa i-spasticity nezinye izimo, ikakhulukazi kulezo ziguli ezinesimo esicashile esingababeka phambili kulezi zimpawu. Ekusetshenzisweni okungagunyaziwe nasezibonisini ezigunyaziwe, izimo zokusabalala komphumela ziye zabikwa ngemithamo eqhathaniswa naleyo esetshenziselwa ukwelapha i-dystonia yomlomo wesibeletho kanye ne-spasticity kanye nemithamo ephansi.

Contraindications
-I-Hypersensitivity kunoma yikuphi ukulungiswa kwe-toxin ye-botulinum noma kunoma yiziphi izingxenye ekwakhiweni
-Ukutheleleka endaweni yomjovo ehlongozwayo

Izexwayiso kanye nezinyathelo zokuqapha
-Ukusabalala kwemiphumela ye-toxin; ukugwinya kanye nobunzima bokuphefumula kungaholela ekufeni. Thola usizo lwezempilo ngokushesha uma kwenzeka kuba nobunzima bokuphefumula, ukukhuluma noma ukugwinya
Amayunithi Amandla we-onabotulinumtoxinA awashintshisana namanye amalungiselelo emikhiqizo yobuthi be-botulinum.
-Ukusabela okubi okungaba khona ngemva kwemijovo ye-onabotulinumtoxinA yokusetshenziswa okungagunyaziwe
-I-neuromuscular disorder ehambisanayo ingase ikhulise imiphumela yomtholampilo yokwelashwa
-Sebenzisa ngokuqapha ezigulini ezinomsebenzi wokuphefumula osengozini
-I-bronchitis kanye nezifo eziphezulu zokuphefumula ezigulini ezilashelwa i-spasticity

Ukusabela Okubi
Ukusabela okungekuhle okuvame kakhulu (≥5% kanye > ne-placebo, uma kusebenza) yilezi:
I-Migraine Engapheli: ubuhlungu bentamo, ikhanda elibuhlungu
-I-Spasticity yabantu abadala: ubuhlungu emaphethelweni
-I-Pediatric Spasticity: ukutheleleka komgudu wokuphefumula ophezulu
I-Cervical Dystonia: i-dysphagia, isifo sokuphefumula esiphezulu, ubuhlungu bentamo, ikhanda elibuhlungu, ukukhwehlela okukhulayo, isifo somkhuhlane, ubuhlungu beqolo, i-rhinitis.

Ukusebenzisana Kwezidakamizwa
-Iziguli ezithola ukwelashwa ngasikhathi sinye kwe-onabotulinumtoxinA nama-aminoglycosides noma amanye ama-ejenti aphazamisa ukudluliswa kwe-neuromuscular (isb., ama-ejenti afana ne-currare), noma iziphumlisi zemisipha, kufanele zibhekwe eduze ngoba umphumela we-onabotulinumtoxinA ungaba namandla.

Sebenzisa Kubantu abathile
-Ukukhulelwa: Ngokusekelwe kudatha yezilwane, kungase kubangele ukulimala kombungu

Sicela ubheke Ulwazi Olugcwele Lokunquma nge-onabotulinumtoxinA. Itholakala ku-http://www.rxabbvie.com.

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